陈春梅

陈春梅简介

博士，副教授，博士生导师，主要从事药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性研究。主持国家自然科学基金青年基金、面上项目，湖北省中央引导地方科技发展资金项目等。以第一作者或通讯作者身份在Angew. Chem. Int. Ed.，Acta Pharmaceutica Sinica B，Chin. Chem. Lett.,Org. Lett.等学术期刊上发表SCI论文80余篇，获国家教学成果二等奖、湖北省科技进步特等奖、教育部工程技术一等奖等。

联系方式

邮箱：chenchunmei@hust.edu.cn

研究方向

药用植物和真菌来源活性天然药物的分离鉴定及药理活性研究

教育及工作经历

2019.10-至今，永利官网，同济060net永利，副教授

2017.8-2019.10，永利官网，同济060net永利，讲师

2015.7-2017.6，永利官网，同济060net永利，博士后

2012.9-2015.6，永利官网，同济060net永利，博士

2009.9-2012.6，西南大学，060net永利，硕士

2005.9-2009.6，西南大学，060net永利，本科

主持科研项目

国家自然科学基金面上项目，编号82373755，2024.1-2027.12（48万）

国家自然科学基金青年项目，编号21602068，2017.1-2019.12（20万）

湖北省中央引导地方科技发展资金项目，2024.12-2026.12（250万）

永利官网人才引进基金，2017.9-2020.8（15万）

中国博士后科学基金面上项目（一等），编号2015M580647，2016.1-2017.6（8万）

主要学术论文

1. Yuyi Zheng(#), Xiaotian Zhang(#), Xiaoxia Gu(#), Yongqi Li(#), Qin Li, Yingli Zhu, Bingbing Dai, Yu Liang, Ruping Fan,Chunmei Chen(*), Weiguang Sun(*), Yonghui Zhang(*), Hucheng Zhu(*). Undulanoids A−D: Unexpected sesterterpenoids as potent S100A8/A9 complex inhibitors for psoriasis treatment.Acta Pharmaceutica Sinica B, 2025, 15, https://doi.org/10.1016/j.apsb.2025.09.006

2. Fengqing Wang^(#), Changxing Qi^(#),Chunmei Chen^(#), Qin Li, Qingyi Tong, Weiguang Sun, Zhengxi Hu, Minyan Wang^(*), Hucheng Zhu^(*), Lianghu Gu^(*), Yonghui Zhang^(*). Discovery and enantioselective total synthesis of antitumor agent asperfilasin A via a regio- and diastereoselective Nazarov cyclization.Chinese Chemical Letters, 2024.(DOI: 10.1016/j.cclet.2024.110252)

3. Aimin Fu^(#),Chunmei Chen^(#), Qin Li^(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei, Weiguang Sun^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungusAspergillus nidulans.Chinese Chemical Letters, 2023, 35, 109100. (DOI:10.1016/j.cclet.2023.109100).

4. Qin Li^(#), Mi Zhang^(#), Xiaotian Zhang^(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu,Chunmei Chen^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons fromTalaromyces stipitatus.Chinese Chemical Letters, 2024, 35, 108193. (DOI: 10.1016/j.cclet.2023.108193).

5. Qin Li, Aimin Fu, Mengsha Wei, Yang Xiao, Jie Yin, Jianzheng Huang, Xiao-Nian Li, Qingyi Tong,Chunmei Chen^(*), Hucheng Zhu^(*), Yonghui Zhang^(*).Asperemestrins A−D, emestrin hybrid polymers with bridged skeletons from the endophytic fungusAspergillus nidulans.Organic Letters, 2022, 24, 6800–6804. (DOI: 10.1021/acs.orglett.2c02701).

6. Zhaodi Wu^(#), Xiaotian Zhang^(#),Chunmei Chen^(#), Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang, Qingyi Tong^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Dimericchalasine A and amichalasines D and E: unexpected cytochalasan homodimer and heterotrimers fromAspergillus micronesiensisPG-1.Organic Letters, 2020, 22, 2162−2166. (DOI: 10.1021/acs.orglett.0c00141).

7. Qin Li^(#),Chunmei Chen^(#), Yan He, Danyingzi Guan, Li Cheng, Xincai Hao, Mengsha Wei, Yinyu Zheng, Chang Liu, Xiao-Nian Li, Qun Zhou,Hucheng Zhu^(*), Yonghui Zhang^(*).Emeriones A−C: three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities fromEmericella nidulans.Organic Letters, 2019, 21, 5091−5095.(DOI: 10.1021/acs.orglett.9b01680).

8. Qin Li^(#),Chunmei Chen^(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang, Weiguang Sun^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Niduterpenoids A and B: two sesterterpenoids with a highly congested hexacyclic 5/5/5/5/3/5 ring system from the fungusAspergillus nidulans.Organic Letters, 2019, 21, 2290−2293. (DOI: 10.1021/acs.orglett.9b00581).

9. Zhaodi Wu^(#), Qingyi Tong^(#), Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang,Chunmei Chen^(*),Hucheng Zhu^(*), Yonghui Zhang^(*).Amichalasines A−C: three cytochalasan heterotrimers fromAspergillus micronesiensisPG-1.Organic Letters, 2019, 21, 1026−1030. (DOI: 10.1021/acs.orglett.8b04066).

10. Guangzheng Wei^(#),Chunmei Chen^(#), Qingyi Tong^(#), Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu^(*), Yonghui Zhang^(*). Aspergilasines A−D: four merocytochalasans with new carbon skeletons fromAspergillus flavipesQCS12.Organic Letters, 2017, 19, 4399−4402. (DOI: 10.1021/acs.orglett.7b02146).

11. Hucheng Zhu^(#),Chunmei Chen^(#), Qingyi Tong^(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, Yonghui Zhang^(*). Asperflavipine A: a cytochalasan heterotetramer uniquely defined by a highly complex tetradecacyclic ring system fromAspergillus flavipesQCS12.Angewandte Chemie International Edition, 2017, 56, 5242−5246. (DOI: 10.1002/anie.201701125)

12. Hucheng Zhu^(#),Chunmei Chen^(#), Jinwen Zhang, Yi Guo, Dongdong Tan, Guangzheng Wei, Jing Yang, Jianping Wang, Zengwei Luo, Yongbo Xue^(*), Yonghui Zhang^(*).Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives fromHypericum sampsonii.Chinese Chemical Letters, 2017, 28, 986−990. (DOI: 10.1016/j.cclet.2016.11.014).

13. Hucheng Zhu^(#),Chunmei Chen^(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang^(*).Epicochalasines A and B: two bioactive merocytochalasans bearing caged epicoccine dimer units fromAspergillus flavipes.Angewandte Chemie International Edition, 2016, 55, 3486−3490. (DOI: 10.1002/ange.201511315).

14. Chunmei Chen^(#), Hucheng Zhu^(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue^(*), Yonghui Zhang^(*).Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungusChaetomium globosum.Organic Letters, 2015, 17, 644−647. (DOI: 10.1021/ol503666b).

15. Hucheng Zhu(#),Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes,Angewandte Chemie International Edition, 2015, 54, 13374−13378.