叶英，女，博士，060net永利副教授，博士生导师。入选湖北省百人计划。博士毕业于日本北海道大学，师从真菌天然产物生物合成领域知名专家HideakiOikawa教授，后在美国密歇根大学天然产物领域著名专家David Sherman教授实验室从事博士后研究。
主要研究方向：微生物/真菌天然产物生物合成及合成生物学，综合运用生物信息学、天然产物化学、基因及蛋白操作、化学合成、计算化学等相关技术，研究天然活性分子的生物合成途径。
联系方式:ying_ye@hust.edu.cn
教育背景
2014.10-2017.10博士，日本北海道大学，生物合成化学（HideakiOikawa教授）
2011.09-2014.03硕士，浙江大学，药学
2007.09-2011.06本科，武汉理工大学，制药工程
工作经历
2018.01-2019.09博士后，美国密歇根大学(Prof. David Sherman)
2019.09至今 副教授，永利官网，同济医学院060net永利
主持及参与项目
国家自然科学基金面上项目，2023.01-2026.12，主持
国家重点研发计划合成生物学重点专项，2021-2026，子课题负责人
国家自然科学基金青年项目，2021.01-2023.12，主持
发表论文
(1)Ye, Y.; Du, L.; Zhang, X.; Newmister, S. A.; McCauley, M.; Alegre-Requena, J. V.; Zhang, W.; Mu, S.; Minami, A.; Fraley, A. E.; Adrover-Castellano, M. L.; Carney, N. A.; Shende, V. V.; Qi, F.; Oikawa, H.; Kato, H.; Tsukamoto, S.; Paton, R. S.; Williams, R. M.; Sherman, D. H.; Li, S. Fungal-Derived Brevianamide Assembly by a Stereoselective Semipinacolase.Nat. Catal.2020,3(6), 497–506.IF 41.8
(2)Ye, Y.; Minami, A.; Igarashi, Y.; Izumikawa, M.; Umemura, M.; Nagano, N.; Machida, M.; Kawahara, T.; Shin‐ya, K.; Gomi, K.; Oikawa, H. Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi.Angew. Chem. Int. Ed.2016,55(28), 8072–8075.IF 11.9
(3)Ye, Y.; Minami, A.; Mandi, A.; Liu, C.; Taniguchi, T.; Kuzuyama, T.; Monde, K.; Gomi, K.; Oikawa, H. Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes.J. Am. Chem. Soc.2015,137(36), 11846–11853.IF 13.0
(4)Li, P.; Meng, J.; Zhang, X.; Zhang, X.; Ye, Y.; Zhao, Y.; Huang, X.; Zha, Z.; Guan, Z.; Lai, S.; Chen, Z.; Luo, Z.; Wang, J.; Chen, C.; Liu, J.; Gu, L.; Sun, Y.; Li, S.; Zhu, H.;Ye, Y.（共通讯）; Zhou, Y.; Zhang, Y. Cooperative Redox Reactions Encoded by Two Gene Clusters Enable Intermolecular Cycloaddition Cascade for the Formation of Meroaspochalasins.Angew. Chem.2025, e202502766.IF 16.1
(5)Hu, Z.;Ye, Y.（共通讯）; Zhang, Y. Large-Scale Culture as a Complementary and Practical Method for Discovering Natural Products with Novel Skeletons.Nat. Prod. Rep.2021,38(10), 1775–1793.IF 15.1
(6)Yuan, W.; Li, F.; Chen, Z.; Xu, Q.; Guan, Z.; Yao, N.; Hu, Z.; Liu, J.; Zhou, Y.;Ye, Y.（共通讯）; Zhang, Y. AbnI: An α-Ketoglutarate-Dependent Dioxygenase Involved in Brassicicene C H Functionalization and Ring System Rearrangement.Chin. Chem. Lett.2024,35(5), 108788.IF 9.4
(7)Guan, Z.; Yao, N.; Yuan, W.; Li, F.; Xiao, Y.; Rehmutulla, M.; Xie, Y.; Chen, C.; Zhu, H.; Zhou, Y.; Tong, Q.; Xiang, Z.;Ye, Y.（共通讯）; Zhang, Y. Total Biosynthesis of Cotylenin Diterpene Glycosides as 14-3-3 Protein–Protein Interaction Stabilizers.Chem. Sci.2025,16(2), 867–875.IF 7.6
(8)Peng, Y.; Luo, S.; Li, Q.; Li, Y.; Zhang, J.; Ding, N.; Sun, W.; Chen, C.; Liu, J.;Ye, Y.（共通讯）; Zhu, H.; Zhang, Y. Discovery of Indole Alkaloids Crienamides A and B fromPenicillium Citrinumby a Simulated MS/MS-Guided Molecular Network Strategy.Org. Lett.2025,27(14), 3673–3678.
(9)Chen, Z.; Yuan, W.; Li, F.; Che, Aw.; Guan, Z.; Hu, Z.; Zhou, Y.; Alegre-Requena, J. V.; Liu, J.;Ye, Y.（共通讯）; Zhang, Y. Scaffold-Adaptive P450 Enzymes Balance Substrate Promiscuity with Catalytic Specificity in Brassicicene Biosynthesis.Org. Lett.2025,27(14), 3595–3600.
(10)Lin, S.; Zhang, X.; Wang, H.; Qiao, Y.; Yu, J.; Peng, Y.; Wang, C.; Cao, F.; Yin, W.-B.; Chen, C.; Zhu, H.; Zhou, Y.; Sun, W.; Hu, Z.; Ye, Y.; Zhang, Y. Diasperonins A–F: Anti-Inflammatory Aspertetronin Dimers Discovered via BBMN and Heterologous Expression Strategy.Org. Lett.2025,27(21), 5435–5439.
(11)Wang, Y.; Duan, Y.; Zhang, M.; Liang, C.; Li, W.; Liu, C.;Ye, Y.（共通讯）Genome Sequencing and Metabolic Potential Analysis of Irpex Lacteus.J. Fungi2024,10(12), 846.
(12)Li, F.; Lai, S.; Yuan, W.; Chen, Z.; Guan, Z.; Chen, C.; Zhu, H.; Zhou, Y.; Winter, J. M.; Xiang, Z.; Liu, J.;Ye, Y.（共通讯）; Zhang, Y. Conformational Control in Diterpene Synthase TlnA: Elucidating the Mechanism of 5–8–6 Skeleton Formation through Ring Expansion.Org. Lett.2024,26(8), 1734–1738.
(13)Li, Q.; Zheng, M.; Li, F.; Li, Y.; Chen, C.; Huang, Z.; Liu, J.; Sun, W.;Ye, Y.（共通讯）; Zhu, H.; Zhang, Y. Talarolactones A–G, α-Pyrone Dimers with Anti-Inflammatory Activities fromTalaromyces Adpressus, and Their Biosynthetic Pathways.Org. Lett.2023,25(10), 1616–1621.
(14)Qiao, Y.; Xu, Q.; Huang, Z.; Chen, X.; Ren, X.; Yuan, W.; Guan, Z.; Li, P.; Li, F.; Xiong, C.; Zhu, H.; Chen, C.; Gu, L.; Zhou, Y.; Qi, C.; Hu, Z.; Liu, J.;Ye, Y.（共通讯）; Zhang, Y. Genome Mining Reveals a New Cyclopentane-Forming Sesterterpene Synthase with Unprecedented Stereo-Control.Org. Chem. Front.2022,9(21), 5808–5818.
(15)Zhao, C.; Yan, S.; Li, Q.; Zhu, H.; Zhong, Z.;Ye, Y.; Deng, Z.; Zhang, Y. An Fe2+‐ and α‐Ketoglutarate‐Dependent Halogenase Acts on Nucleotide Substrates.Angew. Chem. Int. Ed.2020,59(24), 9478–9484.
(16)Fraley, A. E.; Caddell Haatveit, K.;Ye, Y.; Kelly, S. P.; Newmister, S. A.; Yu, F.; Williams, R. M.; Smith, J. L.; Houk, K. N.; Sherman, D. H. Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway.J. Am. Chem. Soc.2020,142(5), 2244–2252.
