朱虎成

博士，教授，博士生导师，公司党委副书记，国家优青，湖北省杰青，国家级一流本科课程《波谱解析》负责人，天然药物化学与资源评价湖北省重点实验室副主任，湖北省药学会中药天然药专业委员会副主任委员。主要从事药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性研究，主持国家自然科学基金优秀青年基金、面上项目，湖北省科技重大项目，湖北省杰出青年基金等，以第一作者或通讯作者身份在Angew. Chem. Int. Ed.，Chem.Sci.,Chin. Chem. Lett.,Org. Lett.等学术期刊上发表SCI论文110余篇，曾获国家教学成果二等奖、湖北省科技进步特等奖、教育部工程技术一等奖、湖北省自然科学奖一等奖等。

联系方式

邮箱：zhuhucheng@hust.edu.cn

研究方向

活性天然药物的分离鉴定、药理活性及成药性研究

教育及工作经历

2024.1-至今，永利官网，同济060net永利，党委副书记

2021.4-2023.12，永利官网，同济060net永利，经理助理

2019.10-至今，永利官网，同济060net永利，教授

2016.9-2019.9，永利官网，同济060net永利，副教授

2014.7-2016.8，永利官网，同济060net永利，博士后

2011.9-2014.6，永利官网，同济060net永利，博士

2008.9-2011.6，西南大学，060net永利，硕士

2004.9-2008.6，西南交通大学，生物工程系，本科

主持科研项目

国家自然科学基金优秀青年基金，编号81922065，2020.1-2022.12（120万）

国家自然科学基金面上项目，编号32570467，2026.1-2029.12（50万）

国家自然科学基金面上项目，编号82173706，2022.1-2025.12（55万）

国家自然科学基金面上项目，编号21772048，2018.1-2021.12（66万）

国家自然科学基金青年项目，编号21502057，2016.1-2018.12（21万）

湖北省科技重大项目，编号2021ACA012，2021.7-2024.6（1000万）

湖北省杰出青年基金项目，编号2018CFA076，2018.3-2021.3（10万）

永利官网基础研究计划，重点项目2023，2024.1-2026.12（100万）

永利官网人才引进基金，编号2006514113，2016.9-2019.8（50万）

中国博士后科学基金特别资助，编号2016T90695，2016.1-2016.12（15万）

中国博士后科学基金面上项目，编号2015M572154，2015.7-2016.6（5万）

代表性学术论文

1. Yuyi Zheng^(#), Xiaotian Zhang^(#), Xiaoxia Gu^(#), Yongqi Li^(#), Qin Li, Yingli Zhu, Bingbing Dai, Yu Liang, Ruping Fan, Chunmei Chen^(*), Weiguang Sun^(*), Yonghui Zhang^(*), Hucheng Zhu^(*). Undulanoids A−D: Unexpected sesterterpenoids as potent S100A8/A9 complex inhibitors for psoriasis treatment.Acta Pharmaceutica Sinica B,2025,15,https://doi.org/10.1016/j.apsb.2025.09.006

2. Pengkun Li^(#), Jie Meng^(#), Xiaotian Zhang^(#), Xiaopeng Zhang, Yonghao Ye, Yunpeng Zhao, Xuenian Huang, Ziou Zha, Zhenhua Guan, Suitian Lai, Zhe Chen, Zengwei Luo, Jianping Wang, Chunmei Chen, Junjun Liu, Lianghu Gu, Yuhui Sun, Shuming Li, Hucheng Zhu^(*), Ying Ye^(*), Yuan Zhou^(*), Yonghui Zhang^(*). Cooperative redox reactions encoded by two gene clusters enable intermolecular cycloaddition cascade for the formation of meroaspochalasins.Angewandte Chemie International Edition,2025,64, e202502766

3. Xiaoxia Gu^(#), Mengzhu Zheng^(#), Ya Gao, Shuang Lin, Xiaotian Zhang, Chunmei Chen, Hucheng Zhu^(*), Weiguang Sun^(*), Yonghui Zhang^(*). Overview of host-directed antiviral targets for future research and drug development.Acta Pharmaceutica Sinica B, 2025,15, 1723–1751.

4. Yuanyang Peng^(#), Shang Luo^(#), Qin Li^(#), Yongqi Li, Jiale Zhang, Nanjin Ding, Weiguang Sun, Chunmei Chen, Junjun Liu, Ying Ye^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Discovery of indole alkaloids crienamides A and B fromPenicillium citrinumby a simulated MS/MS-guided molecular network strategy.Organic Letters, 2025,27,3673–3678.

5. Fengqing Wang^(#), Changxing Qi^(#), Chunmei Chen^(#), Qin Li, Qingyi Tong, Weiguang Sun, Zhengxi Hu, Minyan Wang^(*), Hucheng Zhu^(*), Lianghu Gu^(*), Yonghui Zhang^(*).Discovery and enantioselective total synthesis of antitumor agent asperfilasin aviaa regio- and diastereoselective nazarov cyclization.Chinese Chemical Letters, 2025,36, 109458.

6. Qin Li^(#), Mi Zhang^(#), Xiaotian Zhang^(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu, Chunmei Chen^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons fromTalaromyces stipitatus.Chinese Chemical Letters, 2024, 35, 108193.

7. Aimin Fu^(#), Chunmei Chen^(#), Qin Li^(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei, Weiguang Sun^(*), Hucheng Zhu^(*), Yonghui Zhang^(*). Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungusAspergillus nidulans.Chinese Chemical Letters, 2023, 109100.

8. Qin Li^(#), Meijia Zheng^(#), Fengli Li^(#), Yongqi Li, Chunmei Chen, Zijian Huang, Junjun Liu, Weiguang Sun^(*), Ying Ye^(*), Hucheng Zhu^(*), Yonghui Zhang^(*).Talarolactones A–G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways,Organic Letters, 2023, 25,1616–1621.

9. Qin Li, Aimin Fu, Mengsha Wei, Yang Xiao, Jie Yin, Jianzheng Huang, Xiao-Nian Li, Qingyi Tong, Chunmei Chen^(*), Hucheng Zhu^(*), Yonghui Zhang^(*).Asperemestrins A−D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic FungusAspergillus nidulans,Organic Letters, 2022, 24, 6800–6804.

10. Yi Guo^(#), Fang Huang^(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao-Nian Li, Zengwei Luo, Hucheng Zhu^(*), Xiaochuan Wang^(*), Yonghui Zhang^(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort,Chemical Science,2021, 12, 11438.

11. Huaqiang Li^(#), Wenya Feng^(#), Xiaoxin Li, Xin Kang, Shan Yan, Menghang Chao, Shuyuan Mo, Weiguang Sun, Yuanyuan Lu, Chunmei Chen, Jianping Wang^(*), Hucheng Zhu^(*), and Yonghui Zhang^(*),Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton fromAspergillus terreus,Organic Letters, 2020 22, 7041-7046.

12. Zhaodi Wu^(#), Xiaotian Zhang^(#), Chunmei Chen^(#), Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang, Qingyi Tong⁽*⁾, Hucheng Zhu⁽*⁾, and Yonghui Zhang⁽*⁾, Dimericchalasine A and Amichalasines D and E, Unexpected Cytochalasan Homodimer and Heterotrimers fromAspergillus micronesiensisPG-1,Organic Letters, 2020 22, 2162-2166.

13. Hucheng Zhu^(#), Chunmei Chen^(#), Qingyi Tong^(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang^(*), Asperflavipine A, A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System fromAspergillus flavipesQCS12,Angewandte Chemie-International Edition, 2017, 56, 5242 –5246.

14. Hucheng Zhu^(#), Chunmei Chen^(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang^(*), Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units fromAspergillus flavipes,Angewandte Chemie International Edition, 2016, 55, 3486-3490.

15. Hucheng Zhu^(#), Chunmei Chen^(#), Yongbo Xue^(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang^(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, fromAspergillus flavipes,Angewandte Chemie International Edition, 2015, 54, 13374-13378.