万落生

万落生，永利官网教授，博、硕士研究生导师，中药与天然药物学系副主任。担任国家自然科学基金通讯评审专家、教育部学位论文评审专家、湖北省药品科技咨询专家、武汉市中药专业委员会委员。以第一或通讯作者身份在Angew. Chem. Int. Ed.、Org. Lett.、J. Nat. Prod.、Carbohyd. Polym.等领域权威学术期刊发表SCI论文40余篇，国家授权发明专利1项，主持国家自然科学基金面上项目2项、青年基金1项。

E-mail:wanluosheng@hust.edu.cn;

教育及工作经历

2024.01-至今，永利官网，教授，博、硕士生导师；

2017.11-2023.12，永利官网，副教授，硕士生导师；

2016.09-2017.11，永利官网，讲师，硕士生导师；

2013.07-2016.06，中国科学院昆明植物研究所，药学博士后；

2008.09-2013.06，永利官网，中药药理学，博士学位；

2004.09-2008.06，永利官网，国家生命科学基地班，学士学位.

研究方向

中药药效物质基础与中药质量标准

科研项目与专利

1. 两种黄杨科植物抗神经病理性疼痛的活性生物碱研究，国家自然科学基金面上项目，批准号：32370421，50万元，项目负责人；

2. 以Kv1.3离子通道为靶点的大戟属植物抗银屑病药效物质基础研究，国家自然科学基金面上项目，批准号：31870330，59万元，项目负责人；

3. 滇产三种黄杨属植物抗肿瘤作用及资源品质评价，国家自然科学基金青年项目，批准号：81403050，23万元，项目负责人；

4. 黄连等三种鄂产高品质道地中药材规模化种植及精准扶贫示范研究，科技部国家重点研发计划，750万元，项目参与人；

5. 二萜类化合物及制备方法和应用、二萜类化合物药学上可接受的衍生物、药物组合物及应用，ZL 2021 1 1202584.7.

6. 主持开放课题、横向课题十余项。

部分代表性论文(*corresponding author, #first author)

1. Gong X, Zhang X, Yuan TT, Sun X, Hu Z, Su JC*, Sun W*, Wan Luo-Sheng*.Stelleroids A-C, Three Rearranged Guaiane Sesquiterpenoids with Caged Ring Systems fromStellera chamaejasme.Org. Lett.2025, 27:7991-7996.(JCR Q1,中科院化学一区)

2. Liu G, Sheng Q, Sun X, Meng F, Liu D, Yan L, Wan Luo-Sheng*, Zhou Y*.Base-Catalyzed Chemo-, Regio- and Stereoselective Addition of Quinazolinones to Trifluoromethylated Internal Alkynes for Access to N3-Vinylquinazolinones.Org. Lett.2025, 27:6088-6093.(JCR Q1,中科院化学一区)

3. Xia RF, Wei YR, Zhang CQ, Huang Y, Chen MS, Yuan XY, Zha HJ, Lai KD, Xia X,Wan Luo-Sheng*.Structurally diverse triterpenoids with antibacterial activities fromEuphorbia humifusa.Bioorg. Chem.2024, 127: 106012.(JCR Q1,中科院有机化学一区)

4. Zhang X, Liu G, Sun X, Wan Luo-Sheng*, Zhou Y.A Metal-Free Direct Decarboxylative Fluoroacylation of Indole Carboxylic Acids with Fluorinated Acids.J. Org. Chem.2024,89:14591-14595.(JCR Q1,中科院有机化学二区)

5. Gong Y^#, Liu R^#, Zha H^#, Dong D, Lu N, Yan H,Wan Luosheng*, Nian Y*. AnalgesicBuxusalkaloids with Enhanced Selectivity for the Low-Voltage-Gated Calcium Channel Cav3.2 over Cav3.1 through a New Binding Mode.Angew. Chem. Int. Ed.2024, 63: e202313461.(JCR Q1,中科院化学一区)

6. Cai Q^#, Zha HJ^#, Yuan SY^#, Sun X^#, Lin X, Zheng XY, Qian YX, Xia RF, Luo YS, Shi Z, Su JC*,Wan Luo-Sheng*. Diterpenoids fromEuphorbia fischerianawith Kv1.3 Inhibitory Activity.J. Nat. Prod.2023, 86: 2379-2390.(JCR Q1,中科院药学一区)

7. XiaRF^#, Su JC^#, Yu J^#, Zha HJ, Wu JL, Fu XN, Cai Q,Wan Luo-Sheng*. Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues fromEuphorbia maculata.Phytochemistry2023, 211:113682.(JCR Q1,中科院植物科学二区)

8. Hu ZF^#, Su JC^#, Sun X^#, Xia RF, Wu JL, Fu XN, Zhang BZ*, Chen JC*,Wan Luo-Sheng*. Brujavanoids A-U, structurally diverse apotirucallane-type triterpenoids fromBrucea javanicaand their anti-inflammatory effects.Bioorg. Chem.2022, 127: 106012.(JCR Q1,中科院有机化学一区)

9. Xiang ZN^#, Tong QL^#, Su JC^#, Hu ZF^#, Zhao N, Xia RF, Wu JL, Chen C, Chen JC*,Wan Luo-Sheng*.Diterpenoids with Rearranged 9(10→11)-abeo-10,12-Cyclojatrophane Skeleton and the First (15S)-Jatrophane fromEuphorbia helioscopia: Structural Elucidation, Biomimetic Conversion, and Their Immunosuppressive Effects.Org. Lett.2022, 24: 697-701.(JCR Q1,中科院化学一区)

10. Zhou CG, Xiang ZN, Zhao N, Sun X, Hu ZF, Wu JL, Xia RF, Chen C, Su JC*, Chen JC*,Wan Luo-Sheng*. Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects fromEuphorbia helioscopia.J. Nat. Prod.2022, 85: 815-827.(JCR Q1,中科院药学一区)

11. Pan J^#, Su JC^#, Liu YH, Deng B, Hu ZF, Wu JL, Xia RF, Chen C, He Q, Chen JC*,Wan Luo-Sheng*. Stelleranoids A-M, guaiane-type sesquiterpenoids based on [5,7] bicyclic system fromStellera chamaejasmeand their cytotoxic activity.Bioorg. Chem.2021,115: 105251.(JCR Q1,中科院有机化学一区)

12. Xiang ZN, Su JC, Liu YH, Deng B, Zhao N, Pan J, Hu ZF, Chen FH, Cheng BY, Chen JC*,Wan Luo-Sheng*. Structurally diverse alkaloids fromBuxus sempervirenswith cardioprotective activity.Bioorg. Chem.2021, 109: 104753.(JCR Q1,中科院有机化学一区)

13. Xiang Z, Xie H, Tong Q, Pan J,Wan Luosheng*, Fang J*, Chen J*. Revealing hypoglycemic and hypolipidemic mechanism ofXiaokeyinshuiextract combination on streptozotocin-induced diabetic mice in high sucrose/high fat diet by metabolomics and lipidomics.Biomed. Pharmacother.2021, 135: 111219.(JCR Q1,中科院药学一区)

14. Zhou J, Pan J, Xiang Z, Wang Q, Tong Q, Fang J,Wan Luosheng*, Chen J*.Xiaokeyinshui extract combination, a berberine-containing agent, exerts anti-diabetic and renal protective effects on rats in multi-target mechanisms.J. Ethnopharmacol.2020, 262: 113098.(JCR Q1,中科院药学一区)

15. Wang YL,XiangZN,Yuan Y, ZhouJW,TianLY, ChenJC*,WanLuo-Sheng*.Triterpenoid alkaloids fromBuxus rugulosaand their cytotoxic activities.Phytochem.Lett.2020, 36:86-90.(JCR Q3,中科院植物科学四区)

16. Yuan Y, Wang QY, Zhang J, Nie J, Zhou CG, Yi WQ,Wan Luo-Sheng*, Chen JC*.A new bile acid from the traditional chinese medicineshedan.J.Asian Nat.Prod.Res.2019, PMID: 31535572.(JCR Q3,中科院植物科学四区)

17. Wang Q, Zhou J, Xiang Z, Tong Q, Pan J,Wan Luosheng*, Chen J*.Anti-diabetic and renoprotective effects of Cassiae Semen extract in the streptozotocin-induced diabetic rats.J.Ethnopharmacol.2019, 2019: 111904.(JCR Q1,中科院药学一区)

18. Xiang ZN, Yi WQ, Wang YL, Shao LD, Zhang CQ, Yuan Y, Pan J,Wan Luo-Sheng*, Chen JC*.Buxaustroines A-N, a Series of 17(13→18)abeo-Cycloartenol Triterpenoidal Alkaloids fromBuxus austro-yunnanensisand Their Cardioprotective Activities.J.Nat.Prod.2019, 82:3111-3120.(JCR Q1,中科院药学一区)

19. Wan Luo-Sheng^#, Nian Y^#, Peng XR, Shao LD, Li XN, Yang J, Zhou M*, and Qiu MH*, Pepluanols C–D, Two Diterpenoids with Two Skeletons fromEuphorbia peplus.Org. Lett.2018,20:3074-3120.(JCR Q1,中科院化学一区)

20. Gong Y, Zhang J, Gao F, Zhou J, Xiang Z, Zhou C,Wan Luosheng*, Chen J*. Structure features and in vitro hypoglycemic activities of polysaccharides from different species ofMaidong.Carbohydr. Polym.2017, 173: 215-222.(JCR Q1,中科院化学一区)

21. Bai ST, Zhu GL, Peng XR, Dong JR, Yu MY, Chen JC,Wan Luo-Sheng*, Qiu MH*. Cytotoxicity of Triterpenoid Alkaloids fromBuxus microphyllaagainst Human Tumor Cell Lines.Molecules2016, 21: 1125.(JCR Q2,中科院化学二区)

22. Wan Luo-Sheng^#, Nian Y^#, Ye CJ^#, Shao LD, Peng XR, Geng CA, Zuo ZL, Li XN, Yang J, Zhou M*, Qiu MH*. Three Minor Diterpenoids with Three Carbon Skeletons fromEuphorbia peplus.Org. Lett.2016, 18: 2166-2169.(JCR Q1,中科院化学一区)

23. Wan Luo-Sheng, Shao LD, Fu L, Xu J, Zhu GL, Peng XR, Li XN, Li Yan, Qiu MH*. One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction.Org. Lett.2016, 18: 496-499.(JCR Q1,中科院化学一区)

24. Wan Luo-Sheng, Chu R, Peng XR, Zhu GL, Yu MY, Li L, Zhou L, Lu SY, Dong JR, Zhang ZR, Li Y, Qiu MH*. Pepluane and Paraliane Diterpenoids fromEuphorbia pepluswith Potential Anti-inflammatory Activity.J. Nat. Prod.2016, 79: 1628-1634.(JCR Q1,中科院药学一区)

25. Wan Luo-Sheng, Min QX, Wang YL, Yue YD, Chen JC*. Xanthone Glycoside Constituents ofSwertia kouitchensiswith α-Glucosidase Inhibitory Activity.J. Nat Prod.2013, 76: 1248-1253.(JCR Q1,中科院药学一区)

26. Wan Luo-Sheng, Liu TT, Lin XJ, Min QX, Chen JC*, Two New Chiratane-Type Triterpenoids fromSwertia kouitchensis.Molecules2013, 18: 8518-8523.(JCR Q2,中科院化学二区)

27. Wan Luo-Sheng, Chen CP, Xiao ZQ, Wang YL, Min QX, Yue Y, Chen J*. In vitro and in vivo anti-diabetic activity ofSwertia kouitchensisextract.J. Ethnopharmacol.2013, 147: 622-630.(JCR Q1,中科院药学一区)