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童擎一

来源：060net永利   发布：2018年12月11日 19:03  点击量：

童擎一，博士，副教授，博士生导师，2023年入选湖北省医学青年拔尖人才。2014年6月毕业于四川老员工物治疗国家重点实验室，获医学博士学位，后在永利官网从事博士后研究并留校任教。获2021省自然科学一等奖（5/5）、2024省科学技术进步奖特等奖（14/15）、2023/2025省科协优秀科技论文奖。已发表SCI论文70余篇，总引用近1700，H因子26，其中第一和通讯作者论文34篇（含共同），包括Cell Discovery，Nucleic Acids Research，J. Am. Chem. Soc., Angew. Chem. Int. Ed.，Med Comm，Organic Letters (3篇），Chinese Chemical Letters（2篇）等著名期刊论文（IF大于10的5篇）。主持国自然面上和青年基金项目、湖北省重大科技项目子课题等项目10余项，作为骨干参与国家重点研发计划1项。申请国内专利8项、PCT国际专利1项，已授权2项。承担本科生《药理学》，研究生《药员工物技术》、《应用药理学》等课程的理论和实验教学。作为主讲教师的《药理学》2021年获评省级、2022年获评国家级一流本科课程，《药员工物技术》获评全国药学专业学位研究生精品课程。《药理研究方法学》、《药物毒理学》等教材的编委。任中国药理学会抗炎免疫青委会委员、中国免疫学会中医药免疫分会委员，湖北省毒理学会、药理学会理事。

研究方向：药理学

从病理出发，构建肿瘤、器官损伤、炎症等疾病模型，从新颖天然产物及其衍生物中筛选出活性分子，或从头设计并筛选出具有相关活性的小分子、嵌合分子（PROTAC、ADC）等，并系统研究它们的作用靶点和分子机制。

联系方式

邮箱：qytong@hust.edu.cn

地址：武汉市硚口区航空路13号同济2号楼413/转化医学楼1418

 

主持的科研项目

  1. 湖北省医学青年拔尖人才项目，2024-2027

  2. 国家自然科学基金面上项目，靶向DNA的新型菲啶酮衍生物抗胶质母细胞瘤研究,项目号82073886，2021/01-2024/12

  3. 湖北省科技重大项目子课题，创新药物筛选技术研发与集成子课题（针对重大疾病的小动物模型研发）,项目号2021ACA012，2021/07/01-2024/06/20

  4. 湖北省自然科学基金联合基金项目,金线莲苷在肝窦阻塞综合征中对肝窦内皮细胞的保护作用及机制, 项目号2025AFD070，2025/03/01-2027/03/01

  5. 湖北省中医药管理局面上项目，水仙来源的生物碱及其衍生物抗肿瘤研究,项目号ZY2023M063，2023/01/01-2024/12/31

  6. 湖北省自然科学基金面上项目，小分子化合物ZYH005的抗癌作用靶点研究,项目号2019CFB428，2019/09-2021/08

  7. 永利官网自主创新研究基金，新型菲啶酮衍生物抗肿瘤作用与机制研究,项目号2172019kfyXJJS166，2019/01-2021/12

  8. 国家自然科学基金青年科学基金，葱莲生物碱类化合物的抗白血病作用及机理研究,项目号81503305，2016/01-2018/12

  9. 中国博士后科学基金第66批面上项目，ZYH005及其衍生物抗恶性胶质瘤的作用与机制研究,项目号2019M660125，2018/01-2019/12

  10. 中国博士后科学基金第58批面上项目，文殊兰定碱衍生物ZYH005的抗白血病作用机制研究,项目号2015M582227，2014/08-2016/07

  11. 永利官网博士后科学基金,项目号2006514110，2014/08-2016/07

参编教材

1.《药理研究方法学》2021中国医药科技出版社，编委

2.《药物毒理学》2019/2025中国医药科技出版社第四/五版，编委

主要学术论文(#Co-first author, *Correspondence author,见刊年IF和JCR分区，杂志ISSN，发表年月日）

  1. Zijun Zhang#, Ziming Zhao#, Changxing Qi#, Xiaotian Zhang#, Yang Xiao, Chengjuan Chen, Yu Zou, Xia Chen, Lianghu Gu, Jianzheng Huang, Kun Huang, Ming Xiang, Tiantai Zhang,Qingyi Tong*, Yonghui Zhang*.Butyrolactone I blocks the transition of acute kidney injury to chronic kidney disease in mice by targeting JAK1.MedComm,2025,6(2):e70064.(IF=10.7,Q1,2688-2663,20250121)

  2. Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang,Qingyi Tong*, Yonghui Zhang*.Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure.Cell Discovery,2023,9(1): 77.（IF=13,Q1,2056-5968, 20230725）

  3. Yashuo Zhang#, Yuanlei Cheng#, Qun Luo, Tongbo Wu, Junfeng Huo, Meng Yin, Hui Peng, Yang Xiao,Qingyi Tong*, Huijuan You*.Distinguishing G-Quadruplexes Stabilizer and Chaperone for c-MYC Promoter G-Quadruplexes through Single-Molecule Manipulation.Journal of the American Chemical Society, 2024,146 (6), 3689-3699.（IF=15.1, Q1,0002-7863, 20240131）

  4. Qingyi Tong#, Huijuan You#, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo*, Yonghui Zhang*, ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acidresistance in acute promyelocytic leukemia.Nucleic Acids Research, 2018,46(7):3284–3297.（IF=11.147,Q1,0305-1048, 20180315）

  5. Hucheng Zhu#, Chunmei Chen#,Qingyi Tong#, Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang*, Asperflavipine A, an unprecedented cytochalasan heterotetramer uniquely defined by a highly complicated tetradecacyclic ring system from Aspergillus flavipes QCS12,Angewandte Chemie-International Edition,2017,56(19):5242–5246.（IF=12.102,Q1,1433-7851, 20170424）

  6. Biqiong Zhang#, Ziming Zhao#, Xia Chen#, Fengqing Wang, Zengwei Luo, Lianghu Gu,Qingyi Tong*, Yonghui Zhang*,Kinsenoside derivatives mitigate acute liver injury in mice via MAPK pathway-mediated oxidative stress suppression,Bioorganic Chemistry, 2025, 164, 108840.(IF=4.5, Q1, 0045-2068, 20250811)

  7. Qiaoqiao Tao#,Teng Cai#,Yang Xiao#,Tao Han,Ling Shen,Chang Cheng,Shouying Xu,Aiying Li,Peng Zhang,Jiachun Chen,Yonghui Zhang,Qingyi Tong*,Xiaofeng Cai*.Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity.Bioorganic Chemistry, 2025,160, 108508.(IF=4.5, Q1, 0045-2068, 20250422)

  8. Rehmutulla Mewlude, ZHANG Sitian, YIN Jie, HUANG Jianzheng, XIAO Yang, HU Zhengxi*,TONG Qingyi* , ZHANG Yonghui*,Ustusolate E and 11 α -hydroxy-ustusolate E induce apoptosis incancer cell lines by regulating the PI3K/AKT/mTOR and p-53 pathways.Chinese Journal of Natural Medicines 2025, 23(4): 1-10.（IF=4.0,Q1,2095-6975, 20250420）

  9. Bi-qiong ZHANG†, Feng-qing WANG†, Jie YIN, Xiao-tan YU, Zheng-xi HU, Liang-hu GU#, Qing-yi TONG#, Yong-hui ZHANG#Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma.Current Medical Science 44(5):890-901,2024

  10. Jie Yin#, Longjie Ding#, Si Yao, Jianzheng Huang, Yang Xiao, Yue Wang, Biqiong Zhang, Mewlude Rehmutulla, Lianghu Gu*,Qingyi Tong*, Yonghui Zhang*,Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis.Bioorganic Chemistry, 2024,153，107820.(IF=4.5, Q1,0045-2068, 20240913)

  11. Zhengyi Shi#, Jie Yin#, Yang Xiao, Zhangrong Hou, Fei Song, Jianping Wang,Qingyi Tong*, Changxing Qi*, Yonghui Zhang*. Unprecedented sesquiterpene–polycyclic polyprenylated acylphloroglucinol adduct against acute myeloid leukemia via inhibiting mitochondrial complex V.Chinese Chemical Letters, 2023,35(10)109458.（IF=9.4,Q1, 1001-8417, 20231229）

  12. Yu Liang#, Biqiong Zhang#, Dongyan Li#, Xuanni Chen, Qiwei Wang, Benlong Shu, Qin Li,Qingyi Tong*, Chunmei Chen*, Hucheng Zhu*, Yonghui Zhang*, Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity,Bioorganic Chemistry,2023, 139(1):106736.（IF=4.5, Q1,0045-2068, 20230720）

  13. Nan Qiao#, Zhaohong An#, Zeyu Fu, Xingyu Chen,Qingyi Tong*, Yonghui Zhang*, Hong Ren*. Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke.European Journal of Pharmacology, 949 (2023), 175717. (IF4.2, Q1, 0014-2999, 20230411)

  14. Ping Hu#, Linzhen Hu#, Yizhan Chen#, Fuqian Wang, Yang Xiao, Zhou Tong, Hua Li, Ming Xiang,Qingyi Tong*, Yonghui Zhang*.Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia.Bioorganic Chemistry, 2023, 139, 106701.（IF=4.5, Q1, 0045-2068, 20230625）

  15. Yi Kong#, Jian Jiang#, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang*,Qingyi Tong* and Hongxiang Chen*,Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.Frontiers in Immunology, 2022,13:1094375.（IF=7.3,Q1, 1664-3224, 20230104）

  16. Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, ZilinJin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang*,Qingyi Tong*, Hongxiang Chen*,Endoplasmic reticulum stress in melanoma pathogenesis and resistance.Biomedicine & Pharmacotherapy.2022,155:113741.（IF=7.5,Q1, 0753-3322, 20221001）

  17. Shuang Lin#, Jianzheng Huang#, Hanxiao Zeng,Qingyi Tong*, Xueke Zhang, Beiye Yang, Ying Ye, Jianping Wang, Zhengxi Hu*, Yonghui Zhang*.Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum.Chinese Chemical Letters. 2022 (33) 4587–4594（IF=9.1,Q1, 1001-8417, 20220317）

  18. Xiaotian Zhang#, Zhaodi Wu#,Alan Bao, Ziming Zhao, Yu Chen, Huimin Zhao, Jianping Wang, Chunmei Chen,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*.Asperflavipines C–E and aspermichalasine A: three cytochalasan heterotetramers and an unusual cytochalasan monomer from Aspergillus micronesiensis.Organic Chemistry Frontier, 2022,9, 2585-2592（IF=5.4,Q1, 2052-4129, 20220404）

  19. Yulin Duan#, PingHu#, YiGuo, Pengfei Bu, Zhengyi Shi,Yunfang Cao, Yeting Zhang, Hong Hu,Qingyi Tong*, Changxing Qi*, Yonghui Zhang*. Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim.Phytochemistry.2022 (199) 113166.(IF=3.8, Q1, 0031-9422, 20220401）

  20. Si Yao, Jie Yin, Wen Liu, Yang Li, Jianzheng Huang, Changxing Qi, Zhengxi Hu,Qingyi Tong*, Lianghu Gu*, Yonghui Zhang*. A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma.Bioorganic Chemistry, 2022, 127, 106019.（IF=5.1, Q1, 0045-2068, 20220711）

  21. Beiye Yang#,Jianzheng Huang#,Shuang Lin,Qingyi Tong*, Zeyu Yao, Fengli Li, Ying Ye, Zhengxi Hu *, Yonghui Zhang*, Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton from Hypericum beanie.Organic Chemistry Frontiers, 2021,8, 6411-6418（IF=5.456, Q1, 2052-4129, 20210927）

  22. Mengsha Wei#,Peng Zhou#, Liping Huang, Jie Yin, Qin Li, Chong Dai, Jianping Wang, Lianghu Gu*,Qingyi Tong*, Hucheng Zhu*,Yonghui Zhang*,Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis,Phytochemistry, 2021, 191 112910.(IF=4.0, Q1, 0031-9422, 20210901）

  23. Jiaxiong Ming, Qianqian Xu, Limin Gao, Yanfang Deng, Jie Yin, Qun Zhou*,Qingyi Tong*, Yonghui Zhang*.Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.Pharmaceuticals, 2021,14(5):452.（IF=5.215,Q1,1424-8247, 20210511）

  24. Song Hu#, Jie Yin#, Shan Yan, Ping Hu, Jianzheng Huang, Geng Zhang, Fuqian Wang*,Qingyi Tong*, Yonghui Zhang*, Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways.Bioorganic Chemistry, 2021, 109, 104693.（IF=5.307, Q1, 0045-2068, 20210204）

  25. Zhaodi Wu#; Xiaotian Zhang#, Chunmei Chen#, Peng Zhou, Mi Zhang, Lianghu Gu, ZengweiLuo, Jianping Wang,Qingyi Tong*, Hucheng Zhu*, Yonghui Zhang*, Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from Aspergillus micronesiensis PG-1.Organic Letters,2020，22(6), 2162-2166.（IF=6.005, Q1, 1523-7060, 20200304）

  26. Zhaodi Wu#,Qingyi Tong#, Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen*, Hucheng Zhu*, and Yonghui Zhang*，Amichalasines A–C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1.Organic Letters，2019, 21 (4), 1026–1030.（IF=6.091, Q1, 1523-7060, 20190207）

  27. Yi Guo#,Qingyi Tong#,Na Zhang, Xueyan Duan, Yunfang Cao, Hucheng Zhu, Shuangshuang Xie, Jing Yang, Jinwen Zhang, Yanfei Liu, Yongbo Xue* and Yonghui Zhang*,Highly-functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols fromHypericum perforatuminduce leukemia cell apoptosis.Organic Chemistry Frontiers, 2019,6, 817-824.（IF=5.155, Q1, 2052-4129, 20190131）

  28. Guangzheng Wei#, Chunmei Chen#,Qingyi Tong#, Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu*, and Yonghui Zhang*,Aspergilasines A–D: four merocytochalasans with new carbon skeletons from Aspergillus flavipes QCS12,Organic Letters, 2017, 19, 4399−4402.（IF=6.492, Q1, 1523-7060, 20170807）

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