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齐昌兴

来源：060net永利   发布：2019年09月03日 09:54  点击量：

齐昌兴，博士，永利官网同济医学院060net永利，副教授，入选永利官网“学术新人”（2021）、华中卓越青年学者（2024）。近年来，主持国家自然科学基金面上项目（2024）与青年基金（2020）、湖北省重点研发计划（2025）、湖北省自然科学基金一般面上（2023）、武汉市青年科技晨光计划（2024）等课题；获得教育部科学研究优秀成果一等奖（2025）、湖北省科技进步特等奖（2024）；申请专利7项（已授权1项），科学出版社《天然药物化学》第3版编委。

主要从事基于天然产物的创新药物研究和微量复杂天然产物的发现，致力于从华中地区药用植物及其内生真菌中发掘活性天然先导化合物，并通过化学结构改造与优化、活性评价与药理机制研究等方法发现高效低毒的潜在药物：①基于华中地区药用植物及其微生态圈的新型天然免疫抑制剂研究；②基于土曲霉次级代谢产物的新型GOT1抑制剂与BACE1抑制剂研究；③鄂产金丝桃属植物中多环多异戊烯基酰基间苯三酚类化学成分及生物活性研究。

近年来，共分离和鉴定了天然产物1528个，其中新化合物826个，包括具有全新碳架的多环多异戊烯基酰基间苯三酚类、萜类、聚酮类新骨架化合物89个，隶属于68个不同的新骨架类型，发现具有药用开发潜力的先导化合物4个。以第一作者或通讯作者发表SCI论文72篇（IF > 10论文3篇），其中JCR分区Q1论文57篇，中科院分区1区论文35篇，包括Acta Pharm. Sin. B（IF 14.6）、Adv. Sci.（IF 14.1）、MedComm（IF 10.7）、Chem. Sci.（IF 7.6）、Chinese Chem. Lett.2篇（IF 8.9）、Cell Commun. Signal.（IF 8.9）、J. Agric. Food Chem.2篇（IF 6.2）、Org. Lett.（IF 5.0）、Org. Chem. Front.4篇（IF 4.7）、J Nat. Prod.9篇（IF 3.6）、J. Org. Chem.4篇（IF 3.6）、Chinese J. Chem2篇（IF 5.5）、Bioorg. Chem.8篇（IF 4.7），相关成果被Nature（2020, 586, 64−69）、Nature Reviews Chemistry（2022, 6, 806–822）等期刊论文引用。

 

1.联系方式

邮箱：qichangxing@hust.edu.cn

地址：武汉市硚口区航空路13号同济医学院060net永利1号楼507室；邮编430030

2.教育与工作经历

2020.11至今，永利官网，060net永利，副教授

2024.5~2025.5，国家卫生健康委员会，中国生物技术发展中心，借调干部

2019.7~2020.10，永利官网，060net永利，讲师

2017.6~2019.6，永利官网，基础医学院，博士后，合作导师：张勇慧教授/王小川教授

2018.7~2018.9，德国马尔堡大学，访问学者，合作导师：李书明教授

2012.9~2017.6，永利官网，060net永利，药物化学，博士，导师：张勇慧教授

2008.9~2012.6，湖北中医药大学，060net永利，药学，本科

3.主持科研项目情况

  1. 湖北省重点研发计划，基于生成对抗网络的丁内酯I分子优化：靶向JAK1的急性肾损伤新型候选药物开发，2025BCB029，2025.6~2027.5，400万（省拨经费100万），在研，主持

  2. 国家自然科学基金面上基金项目，基于SPR-AMRS的金丝桃属植物中靶向SGK1的PPAPs类成分挖掘及其抗自身免疫性肝炎研究，32470422，2025.1~2028.12，50万元，在研，主持

  3. 武汉市自然科学基金探索计划，基于湖北药用植物及其微生态圈的新颖小分子TNF-α抑制剂的发现，2024040801020205，2024.6~2026.6，10万元，在研，主持

  4. 湖北省自然科学基金一般面上项目，基于aspulvinone型天然产物的新颖GOT1抑制剂的分子设计、合成及治疗胰腺癌活性研究，2023AFB791，2023.7~2025.6，5万元，结题，主持

  5. 国家自然科学基金青年科学基金项目，烟色拟盘多毛孢中新颖azaphilone类化合物的发现及其靶向GOT1的抗胰腺癌活性研究，82003633，2021.1~2023.12，24万元，结题，主持

  6. 永利官网学术新人特别资助基金，基于天然产物的创新药物研究，0198514058，2022.01~2025.01，20万元，结题，主持

  7. 永利官网人才引进基金，天然药物化学，3004514135，2019.07~2022.07，15万元，结题，主持

  8. 中国博士后科学基金第63批面上项目，杂色曲霉中杂萜类成份及其抗阿尔茨海默病活性的研究，2018.07~2019.06，2018M632879，5万元，结题，主持

4.申请及授权专利情况

  1. 张勇慧，童擎一，张子君，齐昌兴，丁内酯I在制备用于治疗慢性肾病药物中的应用，2024.10.19，中国，CN202410197781.1

  2. 张勇慧，齐昌兴，孙伟光，段玉林，一种间苯三酚化合物、分离及制备抗银屑病药物的应用，2023.11.10，中国，CN2023114959145，已授权

  3. 张勇慧，齐昌兴，孙伟光，陶波，间苯三酚化合物、分离及制备自身免疫性肝炎药物应用，2023.11.10，中国，CN2023115067677，已授权

  4. 张勇慧，齐昌兴，史正义，一种间苯三酚化合物、分离及应用，2023.09.18，中国，CN202311202259X

  5. 张勇慧，陈刚，谭晓晟，齐昌兴，石蒜碱用于制备T细胞免疫抑制剂的应用，2020.08.25，中国，CN202010866444.9

  6. 张勇慧，陈刚，谭晓晟，齐昌兴，一种生物碱用于制备T细胞免疫抑制剂的应用，2023.08.24，中国，CN2023110726767，已授权

  7. 张勇慧，齐昌兴，高炜熙，张锦文，薛永波，汪建平，土壤土曲霉次生代谢产物中抗阿尔茨海默病化合物及分离制备，2020.02.14，中国，ZL201610503931.2，已授权

5.获奖情况

  1. 结构新颖活性天然产物的发现与成药性优化，教育部科学研究优秀成果一等奖，2025年

  2. 天然药物化学研究关键技术与新药创制，湖北省科学技术进步奖特等奖，2024年

6.部分代表性学术论文，#第一作者，*通讯作者

  1. Yeting Zhang(#), Zhengyi Shi(#), Chunhua Zhao(#), Lanqin Li, Ming Chen, Yunfang Cao, Fengqing Wang, Bo Tao, Xinye Huang, Jieru Guo(*),Changxing Qi(*), Weiguang Sun(*), Yonghui Zhang(*). Amoenucles A−F, undescribed nucleoside derivatives with TNF-αinhibitory activities fromAspergillus amoenusTJ507.Chinese Journal of Natural Medicines,2025, 23,111-118.DOI:10.1016/S1875-5364(24)60570-4.

  2. Yulin Duan(#), Xiaoxia Gu(#), Xincai Hao, Guosheng Cao(*), Weiguang Sun(*),Changxing Qi(*),Yonghui Zhang(*). Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity fromHypericum seniawiniiMaxim.Natural Products and Bioprospecting,2025, 15, 40. DOI: 10.1007/s13659-025-00520-z.

  3. Zijun Zhang(#), Ziming Zhao(#),Changxing Qi(#), Xiaotian Zhang(#), Yang Xiao, Chengjuan Chen, Yu Zou, Xia Chen, Lianghu Gu, Jianzheng Huang, Kun Huang, Ming Xiang, Tiantai Zhang, Qingyi Tong(*), Yonghui Zhang(*). Butyrolactone I blocks the transition of acute kidney injury to chronic kidney disease in mice by targeting JAK1.MedComm,2025, 6, e70064. DOI: 10.1002/mco2.70064.

  4. Yeting Zhang(#), Xinye Huang(#), Xinming Song(#), Xuan Li, Jinlong Zhang, Ming Chen, Zhengyi Shi, Binbin Song, Wei Wei(*),Changxing Qi(*), Yonghui Zhang(*). Discovery of cadinane sesquiterpenoids as GOT1 inhibitors fromPenicilliumsp. HZ-5.Bioorganic Chemistry,2025, 157, 108303. DOI: 10.1016/j.bioorg.2025. 10.1016/j.bioorg.2025.108303.

  5. Xueqi Lan(#), Xiaoxia Gu(#), Yeting Zhang(#), Hong Hu, Zhengyi Shi, Chaohu Xiong, Xinye Huang, Binbin Song, Yuben Qiao(*), Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*). Discovery of quorum sensing inhibitors againstPseudomonasaeruginosafromAspergillussp. NB12.Bioorganic Chemistry,2025, 156, 108230. DOI: 10.1016/j.bioorg.2025.108230.

  6. Fengqing Wang(#),Changxing Qi(#), Chunmei Chen(#), Qin Li, Qingyi Tong, Weiguang Sun,Zhengxi Hu, Minyan Wang(*), Hucheng Zhu(*), Lianghu Gu(*), Yonghui Zhang(*).Discovery andenantioselectivetotalsynthesis ofantitumoragentasperfilasin Aviaaregio- anddiastereoselectiveNazarovcyclization.Chinese Chemical Letters,2025,36,110252.doi.org/10.1016/j.cclet.2024.110252.

  7. Yu Zou(#)(*), Yuying He, Lijuan Tan, Xiaofei Xu,Changxing Qi(*),Yonghui Zhang(*).Discovery ofcytotoxicnitricoxide-releasingpiperlonguminederivativestargeting Wnt/β-catenin incoloncancercells.Journal of Natural Products,2024,87, 1893−1902. DOI:org/10.1021/acs.jnatprod.4c00084.

  8. Yeting Zhang(#), Qing Li(#), Jinglong Zhang, Ming Chen, Xuan Li, Yuben Qiao, Kuansong Wang(*),Changxing Qi(*), Yonghui Zhang(*). Eurochevalierines A−I,sesquiterpenealkaloidhybrids withanti-triplenegativebreastcanceractivity fromPenicilliumsp. HZ-5.Journal of Agricultural and Food Chemistry,2024,72, 16801–16811.DOI:10.1021/acs.jafc.4c04011.

  9. Zhengyi Shi(#), Jie Yin(#), Yang Xiao, Zhangrong Hou, Fei Song, Jianping Wang, Qingyi Tong,Changxing Qi(*), Yonghui Zhang(*). Unprecedented sesquiterpene–polycyclic polyprenylated acylphloroglucinol adduct against acute myeloid leukemiaviainhibiting mitochondrial complex V.Chinese Chemical Letters,2024,35,109458. DOI: 10.1016/j.cclet.2023.109458.

  10. Yeting Zhang(#), Jinbing Kang(#), Qun Zhou(#), Ming Chen, Jinlong Zhang, Zhengyi Shi, Yuben Qiao,Changxing Qi(*), Yonghui Zhang(*). Discovery of 23,24-diols containing ergosterols with anti-neuroinflammatory activity fromPenicillium citrinumTJ507.Bioorganic Chemistry,2024,150, 107575.DOI:org/10.1016/j.bioorg.2024.107575.

  11. Yulin Duan(#), Weiguang Sun(#), Yongqi Li(#), Zhengyi Shi, Lanqin Li, Yeting Zhang, Huang Kun, Zhiping Zhang,Changxing Qi(*), Yonghui Zhang(*). Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-αinhibitors with unprecedented chemical architectures.Acta Pharmaceutica Sinica B,2024,14, 2646–2656.DOI:org/10.1016/j.apsb.2024.02.002.

  12. Yulin Duan(#), Bo Tao(#), Zhengyi Shi(#), Yi Guo, Yeting Zhang, Yu Zou(*),Changxing Qi(*), Yonghui Zhang(*). Patumantanes A−D,seco-polycyclic polyprenylated acylphloroglucinols with diverse carbon skeletons fromHypericum patulum.The Journal of Organic Chemistry,2024,89, 8076−8083.DOI:org/10.1021/acs.joc.4c00735.

  13. Yulin Duan(#), Zhengyi Shi(#), Fei Song, Zhangrong Hou, Xiaosheng Tan, Yeting Zhang, Xincai Hao, Gang Chen,Changxing Qi(*), Yonghui Zhang(*). Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols fromHypericum patulum. Chinese Journal of Natural Medicines,2024,22, 1–7.DOI:10.1016/S1875-5364(24)60599-6.

  14. BoTao(#),YongqiLi(#),YulinDuan(#),ZhengyiShi,JieLi,YiGuo,XinyeHuang,YetingZhang,WeiguangSun(*),ChangxingQi(*),YonghuiZhang(*). Discovery of adamantane-type polycyclic polyprenylated acylphloroglucinols that can prevent concanavalin A-induced autoimmune hepatitis in mice.Bioorganic Chemistry,2024,144, 107145.DOI:org/10.1016/j.bioorg.2024.107145.

  15. Hong Hu(#), Lanqin Li(#), Zhengyi Shi(#), Xueqi Lan, Yeting Zhang, Xinye Huang, Xincai Hao, Qun Zhou, Weiguang Sun(*),Changxing Qi(*), Yonghui Zhang(*). Polyaspers A and B, the first ergosterol-polyether adducts with unprecedented 6/6/6/5/5/6/6/6/6 nonacyclic architecture from Aspergillus sp. TJ507.Chinese Journal of Chemistry,2024,42, 743–751.DOI: 10.1002/cjoc.202300649.

  16. Zhengyi Shi(#), Xueyan Duan(#), Fengqing Wang(#), Zhangrong Hou, Fei Song, Lianghu Gu(*),Changxing Qi(*), Yonghui Zhang(*). Maydistacins A–G, Terpestacin-type sesterterpenoids with anti-inflammatory activity from the phytopathogenic fungusBipolaris maydis. Journal of Natural Products,2024,87, 68–76.DOI:org/10.1021/acs.jnatprod.3c00786.

  17. Zhengyi Shi(#), Xiangli Zhao(#), Fei Song, Zhangrong Hou, Xincai Hao, Jieru Guo, Lingjuan Sun, Hao Feng, Meng Wu, Peiling Xie, Xiaosheng Tan, Gang Chen,Changxing Qi(*), Yonghui Zhang(*).Prenyllongnols A–D, new prenylated acylphloroglucinols that fight concanavalin A-induced autoimmune hepatitis.Journal of Agricultural and Food Chemistry,2023,71,17801–17809. DOI:org/10.1021/acs.jafc.3c05245.

  18. Yeting Zhang(#), Xiangli Zhao(#), Yunfang Cao(#), Ming Chen, Zhengyi Shi, Meng Wu, Hao Feng, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan(*), Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*). Bioactive indole alkaloid fromAspergillus amoenusTJ507 that ameliorates hepatic ischemia/reperfusion injury.Journal of Natural Products,2023,86, 2059–2064. DOI: org/10.1021/acs.jnatprod.3c00251.

  19. Hong Hu(#), Yanhui Li(#), Zhengyi Shi(#), Xiangli Zhao, Xueqi Lan, Meng Wu, Bo Tao, Yeting Zhang, Xinye Huang, Pengfei Bu, Yi Guo, Xiaosheng Tan(*),Changxing Qi(*), Yonghui Zhang(*).Discovery of ergosterol derivative fromAspergillussp. TJ507 that protects against hepatic ischemia/reperfusion injury.Bioorganic Chemistry,2023,135, 106530. DOI: org/10.1016/j.bioorg.2023.106530.

  20. Xiaosheng Tan(#),Changxing Qi(#), Xiangli Zhao, Lingjuan Sun, Mi Wu, Weiguang Sun, Lianghu Gu, Fengqing Wang, Hao Feng, Xia Huang, Bin Xie, Zhengyi Shi, Peiling Xie, Meng Wu,Yonghui Zhang(*), Gang Chen(*). ERK inhibition promotes engraftment of allografts by reprogramming T-cell metabolism.Advanced Science,2023, 2206768. DOI: 10.1002/advs.202206768.

  21. Yulin Duan, Yi Guo, Yanfang Deng, Pengfei Bu, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Weiguang Sun,Changxing Qi(*), Yonghui Zhang(*). Norprzewalsone A, a rearranged polycyclic polyprenylated acylphloroglucinol with a spiro[cyclopentane-1,3'-tricyclo[7.4.0.01,6]tridecane] core fromHypericum przewalskii.The Journal of Organic Chemistry,2022,87, 6824−6831. DOI: org/10.1021/acs.joc.2c00503.

  22. Yuben Qiao(#), Xiaosheng Tan(#), Qianqian Xu(#), Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen(*),Changxing Qi(*),Yonghui Zhang(*). Asperosin A, a [4+2] diels–alder cycloaddition polyketide dimer fromAspergillus rugulosawith immunosuppressive activity.Organic Chemistry Frontiers,2022,9, 2477−2485. DOI:org/10.1039/D1QO01767E.

  23. Beiye Yang(#),Changxing Qi(#), Zeyu Yao, Shuang Lin, Fengli Li, Weiguang Sun, Zhengxi Hu(*), Yonghui Zhang(*). Hybeanones A and B, two highly modified polycyclic polyprenylated acylphloroglucinols fromHypericum beanie.Chinese Journal of Chemistry,2021,40, 53–58.DOI: 10.1002/cjoc.202100468.

  24. Mengting Liu(#), Xueke Zhang(#), Ling Shen, Weiguang Sun, Shuang Lin, Junjun Liu, Fei Cao,Changxing Qi, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Bioactive polyketide-terpenoid hybrids from a soil-derived fungusBipolaris zeicola.The Journal of Organic Chemistry,2021, 86, 10962–10974.DOI: 10.1021/acs.joc.0c02237.

  25. Yunfang Cao(#), Xiaosheng Tan(#), Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*). Bioassay-guided isolation of an abetiane-type diterpenoid fromPrunella vulgaristhat protects against concanavalin A-induced autoimmune hepatitis.Journal of Natural Products,2021,84, 2189–2199.DOI:org/10.1021/acs.jnatprod.1c00247.

  26. Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Yi Guo, Zhengyi Shi, Yunfang Cao, Yeting Zhang, Hong Hu, Zhengxi Hu(*),Changxing Qi(*), Yonghui Zhang(*). Discovery of bioactive polycyclic polyprenylated acylphloroglucinols fromHypericum wilsonii.Bioorganic Chemistry,2021,115, 105246.DOI:org/10.1016/j.bioorg.2021.105246.

  27. Yunlin Duan, Shuangshuang Xie, Pengfei Bu, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao, Weiguang Sun,Changxing Qi(*), Yonghui Zhang(*). Hypaluton A, an immunosuppressive 3,4-nor-polycyclic polyprenylated acylphloroglucinol fromHypericum patulum.TheJournal of Organic Chemistry,2021,86, 6478–6485.DOI:org/10.1021/acs.joc.1c00319.

  28. Yulin Duan(#), Yanfang Deng(#), Pengfei Bu, Sshuangshuang Xie, Yi Guo, Zhengyi Shi, Yun Guo, Yunfang Cao,Changxing Qi(*), Yonghui Zhang(*). Discovery ofnor-bicyclic polyprenylated acylphloroglucinols possessing diverse architectures with anti-hepatoma activities fromHypericum patulum.Bioorganic Chemistry,2021,111, 104902.DOI:org/10.1016/j.bioorg.2021.104902.

  29. Shuangshuang Xie(#), Yuan Zhou(#), Xiaosheng Tan(#), Weiguang Sun, Yulin Duan, Hao Feng, Lingjuan Sun, Yi Guo, Zhengyi Shi, Xincai Hao, Gang Chen(*),Changxing Qi(*), Yonghui Zhang(*). Norwilsonnol A, an Immunosuppressive polycyclic polyprenylated acylphloroglucinol with spiro[5-oxatricyclo[6.4.0.03,7]dodecane-6',1-1',2'-dioxane] system fromHypericum wilsonii.Organic Chemistry Frontiers,2021,8, 2280–2286.DOI: 10.1039/D1QO00271F.

  30. Sitian Zhang(#), Yan He(#), Fengli Li, Shuang Lin, Beiye Yang, Shuyuan Mo, Huaqiang Li, Jianping Wang,Changxing Qi(*), Zhengxi Hu(*),Yonghui Zhang(*). Bioassay-directed isolation of antibacterial metabolites from an arthropod-derivedPenicillium chrysogenum.Journal of Natural Products,2020,83, 3397–3403.DOI:org/10.1021/acs.jnatprod.0c00873.

  31. Na Zhang(#), Zhengyi Shi(#), Qianqian Xu(#), Weiguang Sun, Lianghu Gu, Shuangshuang Xie, Yi Guo, Yulin Duan, Kailin Zhang,Changxing Qi(*), Yonghui Zhang(*). Longisglucinols A–C, structurally intriguing polycyclic polyprenylated acylphloroglucinols with anti-inflammatory activity fromHypericum longistylum.Organic Letters,2020,22, 7926–7929.DOI:org/10.1021/acs.orglett.0c02853.

  32. Changxing Qi(#), Xiaosheng Tan(#), Zhengyi Shi, Hao Feng, Lingjuan Sun, Zhengxi Hu(*), Gang Chen(*),Yonghui Zhang(*). Discovery of an oxepine-containing diketopiperazine derivative active against concanavalin A-induced hepatitis.Journal of Natural Products,2020,83, 2672–2678.DOI:org/10.1021/acs.jnatprod.0c00558.

  33. Shuangshuang Xie(#), Xiaosheng Tan(#), Yaping Liu, Yulin Duan, Gang Chen, Hao Feng, Lingjuan Sun, Yingying Huang, Yi Guo, Zhengyi Shi, Yuan Zhou(*),Changxing Qi(*),Yonghui Zhang(*).Hypersonins A−D, polycyclic polyprenylated acylphloroglucinols with a 1,2-seco-jomoadamantane architecture fromHypericum wilsonii.Journal of Natural Products,2020,83, 1804−1809.DOI:org/10.1021/acs.jnatprod.9b01187.

  34. Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun(*), Yuan Zhou(*),Yonghui Zhang(*).Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors.Organic Chemistry Frontiers,2020,7, 1349–1357.DOI: 10.1039/D0QO00259C.

  35. Xueyan Duan(#), Xiaosheng Tan(#), Lianghu Gu(#), Junjun Li, Xincai Hao, Li Tao, Hao Feng, Yunfang Cao, Zhengyi Shi, Yulin Duan, Mengyi Deng, GangChen(*),Changxing Qi(*),Yonghui Zhang(*).New secondary metabolites with immunosuppressive activity from the phytopathogenic fungusBipolaris maydis.Bioorganic Chemistry,2020,99, 103816.DOI:org/10.1016/j.bioorg.2020.103816.

  36. Shuangshuang Xie(#),Changxing Qi(#), Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu(*), Yuan Zhou(*),Yonghui Zhang(*). Wilsonglucinols A−C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols with unusual fused epoxy ring skeletons fromHypericum wilsonii.Organic Chemistry Frontiers,2020,7, 464–471.DOI: 10.1039/C9QO01158G.

  37. Yuben Qiao(#), Qianqian Xu(#), Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang,Changxing Qi(*), Yongbo Xue(*), Yonghui Zhang(*). Asperpyridone A: an unusual pyridone alkaloid exerts hypoglycemic activity through the insulin signaling pathway.Journal of Natural Products,2019,82, 2925–2930.DOI:org/10.1021/acs.jnatprod.9b00188.

  38. Weiguang Sun(#), Shanshan Luan(#),Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), Yonghui Zhang(*). Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.Cell Communication and Signaling,2019,17, 111.DOI: 10.1186/s12964-019-0425-4.

  39. Changxing Qi(#), Mengting Liu(#), Qun Zhou(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*).BACE1 inhibitory meroterpenoids fromAspergillus terreus.Journal of Natural Products,2018,81, 1937−1945.DOI:org/10.1021/acs.jnatprod.7b01050.

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