斯陆勤，永利官网同济医学院060net永利药剂学系，教授，博士生导师
研究方向：新型药物递送系统、药物转运与代谢、群体PKPD建模
主要承担本科生《药剂学》、《生物药剂学与药物动力学》、《老员工批判性思维》、研究生《临床药动学》、《临床药物治疗学》教学工作；主持国家自然科学基金2项，省部级课题多项，参与科技部863课题1项，“十一五”、“十二五”科技部国家重大新药创制项目2项、国家自然科学基金、省部级课题以及企业横向等课题30多项，具有丰富的新制剂研发、DMPK体内外评价相关研究经验；在国内外期刊上发表学术论文100余篇，其中SCI收录论文50多篇，参编国家统编教材6部，获省级科技进步二等奖1项、专利授权3项。
1.工作经历
永利官网，讲师、副教授、教授，2001.07–至今
University ofToronto/060net永利，访问学者（博士后），2011.10–2012.10
2.教育背景
同济医科大学，药学，学士学位，1994.09-1998.06
浙江大学，药剂学，硕士学位，1998.09-2001.06
永利官网，药理学，博士学位，2003.09-2006.06
3.发表论文
Wang Dan#, Chen Wei, Cao Jie,Si Luqin*, Chen Zehong*. Establishment and evaluation of a mouse model of experimental ulcerative colitis induced by the gavage administration of dextran sulfate sodium. Biomedicines. 2024 Aug; 12(8): 1764.
Cao Peng#, Gan Jun#, Wu Sanlan#, Hu Yixin, Xia Bin, Li Xiaoyue, Zeng Hongan, Cheng Bingyu, Yu Huifan, Li Fei,Si Luqin*, Huang Jiangeng*.Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways.Food Chem Toxicol. 2023 Aug;178:113914.
Xiao Chuyao#, Li Genyun#, Li Xiaoyue, Wang Dan, Wu Ya, Sun Minghui, Huang Jiangeng,Si Luqin*.Atopical thermosensitive hydrogel system with cyclosporine A PEG-PCL micelles alleviates ulcerative colitis induced by TNBS in mice.Drug Deliv Transl Res. 2023 Oct;13(10):2447-2462.
Qin Yuling#, Xiao Chuyao, Li Xiaoyue, Huang Jiangeng,Si Luqin*, Sun Minghui*.Enteric Polymer-Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation.Pharmaceutics. 2022 Aug 30; 14(9): 1830.
Zhang Ying#, Sun Minghui, Jian Shuxin, Huang Jiangeng, Xiao Chuyao, Zhang Xiangyu, Hu Ruhao,Si Luqin*.mPEG(2k)-PCLx polymeric micelles influence pharmacokinetics and hypoglycemic efficacy of metformin through inhibition of organic cation transporters in rats. Molecular Pharmaceutics. 2021, Jul 5; 18(7): 2586-2599
Wang Dan#, Sun Minghui, Zhang Ying, Chen Zehong, Zang Shuya, Li Genyun, Li Gao, Huang Jiangeng*,Si Luqin*.Enhanced therapeutic efficacy of a novel colon-specific nanosystem loading emodin on DSS-induced experimental colitis. Phytomedicine. 2020 Nov 1; 78: 15293
WuYa#, Sun Minghui, Wang Dan, Li Genyun, Huang Jiangeng, Tan Songwei, Bao Lin, Li Qian, Li Gao,Si Luqin*. A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.Biomaterials Science, 2019 Oct 1;7(10): 4299-4309.
Li Qian#,Sun Minghui, Li Genyun, Qiu Lihui, Huang Zi, Gong Jingyi, Huang Jiangeng, Li Gao,Si Luqin*, The sub-chronic impact of mPEG2k-PCLxpolymeric nanocarriers on cytochrome P450 enzymes after intravenous administration in rats. European Journal of Pharmaceutics and Biopharmaceutics. 2019 June 18; 142:101-113.
Zhu Wenwen#, Liu Wanyu, Li Haoju, Xu Guojia, Li Qian, Huang Jiangeng,Li Gao,Si Luqin*.Simultaneous quantitation of a novel α₁/β₁-blocker TJ0711 and its two metabolites in dog plasma using LC-MS/MS and its application to a pharmacokinetic study after intravenous infusion.Pharmaceutics. 2019 Jan 18; 11(1): 1-14.
Qiu Lihui#, Li Qian#, Huang Jiangeng, Wu Qi, Tu Kun, Wu Ya, Zhang Xin, Qian Junyi, Zhang Rang, Li Gao, Sun Minghui*,Si Luqin*.In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes.Int J Pharm. 2018 Sep 22; 552(1-2): 99-110.
Hu Yang#,Zhu Wenwen#, Guan Yeli,Wu Sanlan, Zhang Xiaoyin,Li Gao,Si Luqin*, Huang Jiangeng*. Accurate determination of a novel vasodilatory β-blocker TJ0711 using LC-MS/MS: Resolution of an isobaric metabolite interference in dog plasma. Biomed Chromatogr. 2018 Jun; 32(6): e4196.
Kang Li#,Si Luqin#, Rao Jing, Li Dan, Wu Ya, Wu Sanlan, Wu M, He Sijie, Zhu Wenen, Wu Yang, Xu Jiaqiang, Li Gao, Huang Jiangeng*.Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.Toxicol In Vitro. 2017 Apr; 40: 313-323.
Yan Xinjing#, Zhao Shouwei#, Zhu Wenwen, Rao Jing, Kang Li, Xu Jiaqiang, Li Dan, Qin Lixia, Qiu Lihui, Li Gao, Huang Jiangeng,Si Luqin*.LC-MS/MS assay of ropinirole in rat biological matrices: elimination of lysoglycerophosphocholines-based matrix effect.Bioanalysis. 2016 Sep; 8(17): 1823-35.
Guo Yuanyuan#,NiuBoning, Song Qingle, Zhao Yongdan, Bao Yuling, Tan Songwei,Si Luqin*,Zhang Zhiping*.RGD-decorated redox-responsive D-α-tocopherol polyethylene glycol succinate-poly(lactide) nanoparticles for targeted drug delivery.J Materials Chemistry B.2016; 4(13): 2338-2350
Xue Kewen#, Li Gao, Sun Xiao, Hu Ying, Hu Lei, Huang Jiangeng*,Si Luqin*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug.J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15; 990: 141-149.
Hu Lei#, Lv Zhenhua, Li Gao, Xu Xiaolong, Zhang Chenghao, Cao Peng, Huang Jiangeng*,Si Luqin*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultrafast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. 2015 Jun; 38(11): 1837-49.
Guo Weilin#, Li Gao, Yang Yanxia, Yang Conglian,Si Luqin*, Huang Jiangeng*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15; 988: 157-65.
Yang Q Joy#,Si Luqin#, Tang Hui, Sveigaard Helle H, Chow Edwin C, Pang K Sandy*. PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation. Drug Metab Dispos. 2015 Apr; 43(4): 631-45.
联系方式：
E-mail：luqin_si@hust.edu.cn
地址：武汉市硚口区航空路13号同济060net永利 邮编430030
